Abstract Background New Approach Methodologies (NAMs) comprise in silico and in vitro
methods applied as alternative to animal testing. Even though NAMs are already fully …

Excessive enzyme activity often has pathological consequences. This for example is the
case in thrombosis and hereditary angioedema, where serine proteases of the coagulation …

Computational simulations of protein folding can be used to interpret experimental folding
results, to design new folding experiments, and to test the effects of mutations and small …

The making and breaking of clots orchestrated by the thrombotic and thrombolytic serine
protease cascades are critical determinants of morbidity and mortality during infection and …

Tumor initiation and progression are critically dependent on interaction of cancer cells with
their cellular and extracellular microenvironment. Alterations in the composition, integrity …

Retinal neovascular, neurodegenerative, and inflammatory diseases represented by
diabetic retinopathy are the main types of blinding eye disorders that continually cause the …

Background This study aimed to explore predictive biomarkers of coronary collateralization
in patients with chronic total occlusion. Methods and Results By using a microarray …

Serine protease inhibitors (serpins) regulate proteolytic events within diverse biological
processes, including digestion, coagulation, inflammation and immune responses. The …

Serine proteinase inhibitor B9 (serpin B9) is a member of the serine protease inhibitor
superfamily, which is widely found in animals, plants and microorganisms. Serpin B9 has …

The COVID-19 pandemic has resulted in significant morbidity and mortality worldwide.
Management of the pandemic has relied mainly on SARS-CoV-2 vaccines, while alternative …