The biology of ergothioneine, an antioxidant nutraceutical

I Borodina, LC Kenny, CM McCarthy… - Nutrition Research …, 2020 - cambridge.org
Ergothioneine (ERG) is an unusual thio-histidine betaine amino acid that has potent
antioxidant activities. It is synthesised by a variety of microbes, especially fungi (including in …

[HTML][HTML] Oxidative stress and mitochondrial dysfunction in early-onset and late-onset preeclampsia

R Marín, DI Chiarello, C Abad, D Rojas… - … et Biophysica Acta (BBA …, 2020 - Elsevier
Preeclampsia is a pregnancy-specific syndrome with multisystem involvement which leads
to foetal, neonatal, and maternal morbidity and mortality. This syndrome is characterized by …

[HTML][HTML] Ergothioneine, recent developments

IK Cheah, B Halliwell - Redox biology, 2021 - Elsevier
There has been a recent surge of interest in the unique low molecular weight dietary
thiol/thione, ergothioneine. This compound can accumulate at high levels in the body from …

Ergothioneine–a diet‐derived antioxidant with therapeutic potential

B Halliwell, IK Cheah, RMY Tang - FEBS letters, 2018 - Wiley Online Library
Ergothioneine is a thiol/thione molecule synthesised only by some fungi and bacteria.
Nonetheless, it is avidly taken up from the diet by humans and other animals through a …

Administration of pure ergothioneine to healthy human subjects: uptake, metabolism, and effects on biomarkers of oxidative damage and inflammation

IK Cheah, RMY Tang, TSZ Yew, KHC Lim… - Antioxidants & redox …, 2017 - liebertpub.com
Aim: We investigated the uptake and pharmacokinetics of l-ergothioneine (ET), a dietary
thione with free radical scavenging and cytoprotective capabilities, after oral administration …

Distribution and accumulation of dietary ergothioneine and its metabolites in mouse tissues

RMY Tang, IKM Cheah, TSK Yew, B Halliwell - Scientific reports, 2018 - nature.com
L-ergothioneine (ET) is a diet-derived amino acid that accumulates at high concentrations in
animals and humans. Numerous studies have highlighted its antioxidant abilities in vitro …

Ergothioneine levels in an elderly population decrease with age and incidence of cognitive decline; a risk factor for neurodegeneration?

IK Cheah, L Feng, RMY Tang, KHC Lim… - Biochemical and …, 2016 - Elsevier
Ergothioneine (ET), a naturally occurring thione, can accumulate in the human body at high
concentrations from diet. Following absorption via a specific transporter, OCTN1, ET may …

Could ergothioneine aid in the treatment of coronavirus patients?

IK Cheah, B Halliwell - Antioxidants, 2020 - mdpi.com
Infection with SARS-CoV-2 causes the coronavirus infectious disease 2019 (COVID-19), a
pandemic that has, at present, infected more than 11 million people globally. Some COVID …

Ergothioneine as a natural antioxidant against oxidative stress-related diseases

TT Fu, L Shen - Frontiers in Pharmacology, 2022 - frontiersin.org
L-Ergothioneine (EGT) is a natural antioxidant derived from microorganisms, especially in
edible mushrooms. EGT is found to be highly accumulated in tissues that are susceptible to …

Ergothioneine, an adaptive antioxidant for the protection of injured tissues? A hypothesis

B Halliwell, IK Cheah, CL Drum - Biochemical and Biophysical Research …, 2016 - Elsevier
Ergothioneine (ET) is a diet-derived, thiolated derivative of histidine with antioxidant
properties. Although ET is produced only by certain fungi and bacteria, it can be found at …