Clinical question What is the role of drugs in preventing covid-19? Why does this matter?
There is widespread interest in whether drug interventions can be used for the prevention of …

Clinical trial endpoints must be carefully and intentionally selected so that the results of the
trial can be used to inform policy-and decision-making. The relative importance of potential …

Despite the urgent need for effective antivirals against SARS-CoV-2 to mitigate the
catastrophic impact of the COVID-19 pandemic, favipiravir and ivermectin are among the …

Background The COVID-19 pandemic affected all WHO member states. We compared and
contrasted the COVID-19 treatment guidelines of each member state with the WHO COVID …

We thank Bram Rochwerg and colleagues for information on the WHO therapeutic guideline
development process. Unfortunately, they do not address our main concern: the unjustified …

Background: The COPCOV study (chloroquine/hydroxychloroquine prevention of
coronavirus disease), which started recruitment in April 2020, is a multi-country double …

Background At the beginning of the coronavirus disease (COVID-19) pandemic,
hydroxychloroquine (HCQ) was widely used as a possible antiviral agent. Current …

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Abstract The CEP/CONEP System, submitted to social control, is responsible for the ethical
approval of research in Brazil to protect research participants. The Informed Consent Form …

Despite the enormity of COVID-19 pandemic and the many hundreds of clinical trials
evaluating putative therapeutics, there have been very few randomised controlled trials …