BACKGROUND A normal chromosomal constitution defined through PGT-A assessing all
chromosomes on trophectoderm (TE) biopsies represents the strongest predictor of embryo …

Recurrent implantation failure refers to failure to achieve a clinical pregnancy after transfer of
at least four good-quality embryos in a minimum of three fresh or frozen cycles in a woman …

One week after fertilization, human embryos implant into the uterus. This event requires the
embryo to form a blastocyst consisting of a sphere encircling a cavity lodging the embryo …

Understanding lineage specification during human pre-implantation development is a
gateway to improving assisted reproductive technologies and stem cell research. Here we …

Background Elective single embryo transfer (eSET) has been increasingly advocated, but
concerns about the lower pregnancy rate after reducing the number of embryos transferred …

Studies of cultured embryos have provided insights into human peri-implantation
development. However, detailed knowledge of peri-implantation lineage development as …

Our understanding of how human embryos develop before gastrulation, including spatial
self-organization and cell type ontogeny, remains limited by available two-dimensional …

Visual morphology assessment is routinely used for evaluating of embryo quality and
selecting human blastocysts for transfer after in vitro fertilization (IVF). However, the …

Chromosomal instability leading to aneuploidy is pervasive in early human embryos,–and is
considered as a major cause of infertility and pregnancy wastage,. Here we provide several …

STUDY QUESTION Can a deep learning model predict the probability of pregnancy with
fetal heart (FH) from time-lapse videos? SUMMARY ANSWER We created a deep learning …