This review describes the structure and functions of Y-box binding protein 1 (YB-1) and its
homologs. Interactions of YB-1 with DNA, mRNAs, and proteins are considered. Data on the …

CTCF is an evolutionarily conserved zinc finger (ZF) phosphoprotein that binds through
combinatorial use of its 11 ZFs to∼ 50 bp target sites that have remarkable sequence …

The Y‐box‐binding protein (YB‐1) represents the most evolutionary conserved nucleic‐acid‐
binding protein currently known. YB‐1 is a member of the cold‐shock domain (CSD) protein …

Insulators can block an enhancer of one gene from activating a promoter on another nearby
gene. Almost all described vertebrate insulators require binding of the regulatory protein …

Abstract Cys2-His2 (C2H2) zinc finger domains (ZFs) were originally identified as DNA-
binding domains, and uncharacterized domains are typically assumed to function in DNA …

When placed between an enhancer and promoter, certain DNA sequence elements inhibit
enhancer-stimulated gene expression. The best characterized of these enhancer-blocking …

Three decades of research have established the CCCTC-binding factor (CTCF) as a
ubiquitously expressed chromatin organizing factor and master regulator of gene …

Chromatin insulators are boundary elements between distinctly regulated, neighboring
chromosomal domains, and they function by blocking the effects of nearby enhancers in a …

Chromatin insulators demarcate expression domains by blocking the cis effects of
enhancers or silencers in a position-dependent manner,. We show that the chromatin …

The transcription factor c‐Myc is a key regulator of cell proliferation, cell growth,
differentiation, and apoptosis. Deregulated c‐myc expression possesses a high …