Vascular epidermal growth factor receptor-2 (VEGFR-2), as an important tyrosine
transmembrane protein, plays an important role in regulating endothelial cell proliferation …

There has been substantial attention in the expansion of new thiosemicarbazide derivatives
with diverse biological activities in recent years. Therefore, many scientists have prepared …

A new series of pyrimidine-5-carbonitrile derivatives has been designed as ATP mimicking
tyrosine kinase inhibitors of the epidermal growth factor receptor (EGFR). These compounds …

Vascular endothelial growth factor-2 (VEGFR-2) is considered one of the most important
factors in tumor angiogenesis, and consequently a number of anticancer therapeutics have …

Eleven new quinoxaline derivatives were designed and synthesized as modified VEGFR-2
inhibitors of our previous work. The synthesized compounds were tested against three …

Guided by the structural optimization principle and the promising anticancer effect of the
quinoxaline nucleus, a new series of novel HDAC inhibitors were designed and …

This study was focused on the synthesis of new pyrimidines 4a, b, 5a, b and pyrazoles 6a, b
as ATP mimicking tyrosine kinase inhibitors of the epidermal growth factor receptor (EGFR) …

Heterocyclic derivatives as a major group of organic compounds are enormously used for a
wide range of pharmaceutical and industrial applications. They are known for their biological …

Deregulation of many kinases is directly linked to cancer development and the tyrosine
kinase family is one of the most important targets in current cancer therapy regimens. In this …

Despite significant improvements of new treatment options, cancer continues to represent as
one of the most common and fatal disease. The EGFR signaling pathway is considered as a …