Efficient and regulated nucleocytoplasmic trafficking of macromolecules to the correct
subcellular compartment is critical for proper functions of the eukaryotic cell. The majority of …

Proteins in the karyopherin-β family mediate the majority of macromolecular transport
between the nucleus and the cytoplasm. Eleven of the 19 known human karyopherin-βs and …

The movement of proteins between the cytoplasm and nucleus mediated by the importin
superfamily of proteins is essential to many cellular processes, including differentiation and …

Central to eukaryotic cell function, transport into and out of the nucleus is largely mediated
by members of the Importin (IMP) superfamily of transporters of α-and β-types. The first …

During interphase, the transport receptor importin-β carries cargoes into the nucleus, where
RanGTP releases them. A similar mechanism operates in mitosis to generate a gradient of …

The nuclear transport proteins, importins and exportins (karyopherin-β proteins), may play
an important role in cancer by transporting key mediators of oncogenesis across the nuclear …

The nuclear localization of specific proteins is critical for cellular processes such as cell
division, and in recent years perturbation of the nuclear transport cycle of key proteins has …

Nuclear transport receptors of the karyopherin superfamily of proteins transport
macromolecules from one compartment to the other and are critical for both cell physiology …

The intracellular location and regulation of proteins within each cell is critically important and
is typically deregulated in disease especially cancer. The clinical hypothesis for inhibiting …

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are fatal
neurodegenerative disorders on a disease spectrum that are characterized by the …