Mitochondria are traditionally known as the powerhouse of the cell, but their functions
extend far beyond energy production. They are vital in cellular and organismal pathways …

Intrinsically disordered proteins and protein regions (IDRs) are abundant in eukaryotic
proteomes and play a wide variety of essential roles. Instead of folding into a stable …

Protein lysine acetylation is an important posttranslational modification that regulates
numerous biological processes. Targeting lysine acetylation regulatory factors, such as …

Diabetes promotes the development of both heart failure with a reduced ejection fraction
and heart failure with a preserved ejection fraction through diverse mechanisms, which are …

Cellular organelles are not static but show dynamism—a property that is likely relevant for
their function. In addition, they interact with other organelles in a highly dynamic manner. In …

Sodium-glucose cotransporter 2 inhibitors reduce the risk of serious heart failure and
adverse renal events, but the mechanisms that underlie this benefit are not understood …

Mitochondria-associated endoplasmic reticulum membrane (MAM) may have a role in
tubular injury in diabetic nephropathy (DN), but the precise mechanism remains unclear …

PACS1 syndrome is a neurodevelopmental disorder (NDD) caused by a recurrent de novo
missense mutation in PACS1 (p. Arg203Trp (PACS1R203W)). The mechanism by which …

Abstract Imbalanced Sirtuin 1 (SIRT1) levels may lead to liver diseases through abnormal
regulation of autophagy, but the roles of SIRT1-regulated autophagy in hepatocellular …

Abstract Sodium-glucose co-transporter 2 (SGLT2) inhibitors reduce the risk of serious heart
failure events, even though SGLT2 is not expressed in the myocardium. This …