Unravelling coagulation factor-mediated cellular signalling
JS O'Donnell, H Fleming, D Noone… - Journal of Thrombosis and …, 2023 - Elsevier
Blood coagulation is initiated in response to blood vessel injury or pro-inflammatory stimuli,
which activate coagulation factors to coordinate the complex biochemical and cellular …
which activate coagulation factors to coordinate the complex biochemical and cellular …
Hot under the clot: venous thrombogenesis is an inflammatory process
Venous thrombosis (VT) is a serious medical condition in which a blood clot forms in deep
veins, often causing limb swelling and pain. Current antithrombotic therapies carry …
veins, often causing limb swelling and pain. Current antithrombotic therapies carry …
The aptamer BT200 blocks interaction of K1405-K1408 in the VWF-A1 domain with macrophage LRP1
Rondaptivon pegol (previously BT200) is a pegylated RNA aptamer that binds to the A1
domain of von Willebrand factor (VWF). Recent clinical trials demonstrated that BT200 …
domain of von Willebrand factor (VWF). Recent clinical trials demonstrated that BT200 …
VWF–ADAMTS13 axis dysfunction in children with sickle cell disease treated with hydroxycarbamide vs blood transfusion
Previous studies have reported elevated von Willebrand factor (VWF) levels in patients with
sickle cell disease (SCD) and demonstrated a key role for the VWF-ADAMTS13 axis in the …
sickle cell disease (SCD) and demonstrated a key role for the VWF-ADAMTS13 axis in the …
The in vitro gastrointestinal digestion-associated protein corona of polystyrene nano-and microplastics increases their uptake by human THP-1-derived macrophages
H Brouwer, M Porbahaie, S Boeren, M Busch… - Particle and Fibre …, 2024 - Springer
Abstract Background Micro-and nanoplastics (MNPs) represent one of the most widespread
environmental pollutants of the twenty-first century to which all humans are orally exposed …
environmental pollutants of the twenty-first century to which all humans are orally exposed …
Pathometagenomics reveals susceptibility to intestinal infection by Morganella to be mediated by the blood group-related B4galnt2 gene in wild mice
M Vallier, A Suwandi, K Ehrhardt, M Belheouane… - Gut …, 2023 - Taylor & Francis
Infectious disease is widely considered to be a major driver of evolution. A preponderance of
signatures of balancing selection at blood group-related genes is thought to be driven by …
signatures of balancing selection at blood group-related genes is thought to be driven by …
Proteomic changes of the bovine blood plasma in response to heat stress in a tropically adapted cattle breed
Background Identifying molecular mechanisms responsible for the response to heat stress is
essential to increase production, reproduction, health, and welfare. This study aimed to …
essential to increase production, reproduction, health, and welfare. This study aimed to …
[HTML][HTML] High-resolution omics of vascular ageing and inflammatory pathways in neurodegeneration
High-resolution omics, particularly single-cell and spatial transcriptomic profiling, are rapidly
enhancing our comprehension of the normal molecular diversity of gliovascular cells, as well …
enhancing our comprehension of the normal molecular diversity of gliovascular cells, as well …
Diagnosis and treatment of von Willebrand disease in 2024 and beyond
Manuscript background and aim The diagnosis and clinical care of patients with von
Willebrand disease (VWD) has continued to evolve since the characterization of the von …
Willebrand disease (VWD) has continued to evolve since the characterization of the von …
Effects of coagulation factors on bone cells and consequences of their absence in haemophilia a patients
G Battafarano, S Lancellotti, M Sacco, M Rossi… - Scientific Reports, 2024 - nature.com
Haemophilia is associated with reduced bone mass and mineral density. Due to the rarity of
the disease and the heterogeneity among the studies, the pathogenesis of bone loss is still …
the disease and the heterogeneity among the studies, the pathogenesis of bone loss is still …