Inwardly rectifying K+ (Kir) channels allow K+ to move more easily into rather than out of the
cell. They have diverse physiological functions depending on their type and their location …

GABAB receptors are broadly expressed in the nervous system and have been implicated in
a wide variety of neurological and psychiatric disorders. The cloning of the first GABAB …

To study the role of G protein-coupled, inwardly rectifying K+(GIRK) channels in mediating
neurotransmitter actions in hippocampal neurons, we have examined slices from transgenic …

The striatum and its ventral extension, the nucleus accumbens, are involved in behaviors as
diverse as motor planning, drug seeking, and learning. Invariably, these striatally mediated …

The γ-aminobutyric acidB (GABAB) receptor was first demonstrated on presynaptic terminals
where it serves as an autoreceptor and also as a heteroreceptor to influence transmitter …

Synapses are continually regulated by chemical modulators and by their own activity. We
tested the specificity of regulation in two excitatory pathways of the neocortex …

Major depression is a debilitating and recurrent disorder with a substantial lifetime risk and a
high social cost. Depressed patients generally display co-morbid symptoms, and depression …

The nature and value of various animal models of epilepsy for the study and understanding
of the human epilepsies are reviewed, with special reference to the ILAE classification of …

Activation of presynaptic receptors for a variety of neurotransmitters and neuromodulators
inhibits transmitter release at many synapses. Such presynaptic inhibition might serve as a …

The inhibitory neurotransmitter GABA acts in the mammalian brain through two different
receptor classes: GABAA and GABAB receptors. GABAB receptors differ fundamentally from …