Food allergy, mechanisms, diagnosis and treatment: Innovation through a multi‐targeted approach

SB Sindher, A Long, AR Chin, A Hy, V Sampath… - Allergy, 2022 - Wiley Online Library
The incidence of food allergy (FA) has continued to rise over the last several decades,
posing significant burdens on health and quality of life. Significant strides into the …

Intestinal mucus barrier: a missing piece of the puzzle in food allergy

A Parrish, M Boudaud, A Kuehn, M Ollert… - Trends in Molecular …, 2022 - cell.com
The prevalence of food allergies has reached epidemic levels but the cause remains largely
unknown. We discuss the clinical relevance of the gut mucosal barrier as a site for allergic …

Treatment of peanut allergy and colitis in mice via the intestinal release of butyrate from polymeric micelles

R Wang, S Cao, MEH Bashir, LA Hesser, Y Su… - Nature Biomedical …, 2023 - nature.com
The microbiome modulates host immunity and aids the maintenance of tolerance in the gut,
where microbial and food-derived antigens are abundant. Yet modern dietary factors and …

Specific gut microbiome signatures and the associated pro-inflamatory functions are linked to pediatric allergy and acquisition of immune tolerance

F De Filippis, L Paparo, R Nocerino… - Nature …, 2021 - nature.com
Understanding the functional potential of the gut microbiome is of primary importance for the
design of innovative strategies for allergy treatment and prevention. Here we report the gut …

Early intervention and prevention of allergic diseases

HA Brough, BJ Lanser, SB Sindher, JMC Teng… - Allergy, 2022 - Wiley Online Library
Food allergy (FA) is now one of the most common chronic diseases of childhood often
lasting throughout life and leading to significant worldwide healthcare burden. The precise …

[HTML][HTML] Allergy, anaphylaxis, and nonallergic hypersensitivity: IgE, mast cells, and beyond

J Vitte, S Vibhushan, M Bratti… - Medical Principles and …, 2022 - karger.com
IgE-mediated type I hypersensitivity reactions have many reported beneficial functions in
immune defense against parasites, venoms, toxins, etc. However, they are best known for …

The role of gut microbiota and leaky gut in the pathogenesis of food allergy

R Poto, W Fusco, E Rinninella, M Cintoni, F Kaitsas… - Nutrients, 2023 - mdpi.com
Food allergy (FA) is a growing public health concern, with an increasing prevalence in
Western countries. Increasing evidence suggests that the balance of human gut microbiota …

Pivotal interplays between fecal metabolome and gut microbiome reveal functional signatures in cerebral ischemic stroke

L Zhao, C Wang, S Peng, X Zhu, Z Zhang… - Journal of Translational …, 2022 - Springer
Background Integrative analysis approaches of metagenomics and metabolomics have
been widely developed to understand the association between disease and the gut …

Systematic review of the association between short chain fatty acids and allergic diseases

M Sasaki, NHA Suaini, J Afghani, KN Heye… - Allergy, 2024 - Wiley Online Library
We performed a systematic review to investigate the current evidence on the association
between allergic diseases and short chain fatty acids (SCFAs), which are microbially …

Early‐life fecal metabolomics of food allergy

KA Lee‐Sarwar, YC Chen, J Lasky‐Su, RS Kelly… - Allergy, 2023 - Wiley Online Library
Background Intestinal microenvironmental perturbations may increase food allergy risk. We
hypothesize that children with clinical food allergy, those with food sensitization, and healthy …