BACKGROUND: The cytosolic glutathione transferases (GSTs) comprise a super family of
proteins that can be categorized into multiple classes with a mixture of highly specific and …

Glutathione S-transferases (GSTs) are phase II detoxifying enzymes involved in the
maintenance of cell integrity, oxidative stress and protection against DNA damage by …

Oxidative stress causes damage to multiple cellular components such as DNA, proteins, and
lipids, and is implicated in various human diseases including cancer, neurodegeneration …

Modulation of the metabolism and disposition of carcinogens through induction of
cytoprotective enzymes is one of several promising strategies to prevent cancer …

Cancer is a serious problem affecting the health of all human societies. Chemotherapy
refers to the use of drugs to kill cancer or the origin of cancer. In the past three decades …

Abstract Purpose Procyanidin B2 (PB2) is a naturally occurring flavonoid widely found in
cocoa, red wine and grape juice. Recent studies have suggested that PB2 could protect …

Inactivation of glutathione S-transferase pi 1 (GSTP1) via hypermethylation is an early and
common event in prostate carcinogenesis. Functional inactivation of GSTP1 increases the …

Abstract Nuclear Factor kappa B (NF-κB) is a transcription factor family critical in the
activation of pro-inflammatory responses. The NF-κB pathway is regulated by oxidant …

The pi‐class glutathione S‐transferase (GSTP1) actively protect cells from carcinogens and
electrophilic compounds. Loss of GSTP1 expression via promoter hypermethylation is the …

Abstract Glutathione S-transferase P (GSTP), and possibly other members of the subfamily
of cytosolic GSTs, are increasingly proposed to have roles far beyond the classical GSH …