Peptide neurotransmitters and peptide hormones, collectively known as neuropeptides, are
required for cell-cell communication in neurotransmission and for regulation of endocrine …

Virtual screening is increasingly being used in drug discovery programs with a growing
number of successful applications. Experimental methodologies developed to speed up the …

The novel emerged SARS-CoV-2 has rapidly spread around the world causing acute
infection of the respiratory tract (COVID-19) that can result in severe disease and lethality …

There are virtually no clinically available neuroprotective drugs for the treatment of acute
and chronic neurological disorders, hence there is an urgent need for the development of …

Analysis of the SARS-CoV-2 sequence revealed a multibasic furin cleavage site at the
S1/S2 boundary of the spike protein distinguishing this virus from SARS-CoV. Furin, the best …

Proprotein convertases (PCs) are highly specific proteases required for the proteolytic
modification of many secreted proteins. An unbalanced activity of these enzymes is …

In eukaryotes, many secreted proteins and peptide hormones are excised from larger
precursors by calcium-dependent serine proteinases, the proprotein/prohormone …

Optimization of our previously described peptidomimetic furin inhibitors was performed and
yielded several analogs with a significantly improved activity. The most potent compounds …

The threat of bioterrorism and the potential use of biological weapons against both military
and civilian populations has become a major concern for governments around the world. For …

Furin belongs to the family of proprotein convertases (PCs) and is involved in numerous
normal physiological and pathogenic processes, such as viral propagation, bacterial toxin …