Some recent clinical and preclinical evidence suggests that neuroinflammation is a key
factor that interacts with the three neurobiological correlates of major depressive disorder …

Serotonin is a phylogenetically ancient biogenic amine that has played an integral role in
maintaining energy homeostasis for billions of years. In mammals, serotonin produced …

Tryptophan metabolites are known to participate in the regulation of many cells of the
immune system and are involved in various immune-mediated diseases and disorders …

NAD+ is a fundamental molecule in human life and health as it participates in energy
metabolism, cell signalling, mitochondrial homeostasis, and in dictating cell survival or …

Research on the neurobiology of the kynurenine pathway has suffered years of relative
obscurity because tryptophan degradation, and its involvement in both physiology and major …

The essential amino acid tryptophan is not only a precursor of serotonin but is also
degraded to several other neuroactive compounds, including kynurenic acid, 3 …

Diseases of the central nervous system (CNS) remain a significant health, social and
economic problem around the globe. The development of therapeutic strategies for CNS …

The autonomic nervous system is one of the major neural pathways activated by stress. In
situations that are often associated with chronic stress, such as major depressive disorder …

The kynurenine pathway (KP) of tryptophan metabolism has emerged in recent years as a
key regulator of the production of both neuroprotective (eg kynurenic and picolinic acid, and …

Various pathologies of the central nervous system (CNS) are accompanied by alterations in
tryptophan metabolism. The main metabolic route of tryptophan degradation is the …