The conversion of an epithelial cell to a mesenchymal cell is critical to metazoan
embryogenesis and a defining structural feature of organ development. Current interest in …

For almost 30 years, the cell-surface protein CD34 has been widely used as a marker to
assist in the identification and isolation of hematopoietic stem cells (HSCs) and progenitors …

After emigration from the bone marrow into the peripheral blood, monocytes enter tissues
and differentiate into macrophages. Monocytes/macrophages have many roles in immune …

Podocalyxin, a sialomucin most closely related to CD34 and endoglycan, is expressed by
kidney podocytes, hematopoietic progenitors, vascular endothelia, and a subset of neurons; …

Future therapeutic applications of differentiated human embryonic stem cells (hESC) carry a
risk of teratoma formation by contaminating undifferentiated hESC. We generated 10 …

An emerging point of view in protein chemistry is that proteins are not the static objects that
are displayed in textbooks but are instead dynamic actors. Protein dynamics plays a …

We have previously identified the cell adhesion protein podocalyxin expressed in a human
pluripotent stem cell, embryonal carcinoma (EC), which is a malignant germ cell …

Establishment and maintenance of apico-basal polarity in epithelial organs must be tightly
coupled with cell division, but the underlying molecular mechanisms are largely unknown …

In the testicular cancer cell line, NT2, we previously demonstrated that differentially
methylated regions were located in introns or intergenic regions, and postulated these might …

Phagocytes remove dead and dying cells by engaging" eat-me" ligands such as
phosphatidylserine (PtdSer) on the surface of apoptotic targets. However, PtdSer is …