Eicosanoids, including prostaglandins and leukotrienes, are biologically active lipids that
have been implicated in various pathological processes, such as inflammation and cancer …

Multidrug transporter proteins are best known for their contributions to chemoresistance
through the efflux of anticancer drugs from cancer cells. However, a considerable body of …

Although successful for a limited number of tumour types, the efficacy of cancer therapies,
especially for late-stage disease, remains poor overall. Many have argued that this could be …

Inflammation in the tumor microenvironment is now recognized as one of the hallmarks of
cancer. Endogenously produced lipid autacoids, locally acting small molecule lipid …

Gingerol, a natural component of ginger, exhibits anti-inflammatory and antitumorigenic
activities. Despite its potential efficacy in cancer, the mechanism by which [6]-gingerol exerts …

This article reviews progress in chemopreventive drug development, especially data and
concepts that are new since the 2002 AACR report on treatment and prevention of …

The essential fatty acids, linoleic acid and arachidonic acid play an important role in
pancreatic cancer development and progression. These fatty acids are metabolized to …

Since antiquity, ginger or Zingiber officinale, has been used by humans for medicinal
purposes and as spice condiments to enhance flavor in cooking. Ginger contains many …

Purpose: Arachidonic acid metabolism via the cyclooxygenase (COX) and 5-lipoxygenase
(5-LOX) pathways modulates cell growth and apoptosis. Many studies have examined the …

Purpose: Previous studies have suggested an important role of aberrant arachidonic acid
metabolism, especially the cyclooxygenase (Cox) pathway, in oral carcinogenesis …