Helicobacter pylori is one of the main causal risk factor in the generation of chronic gastritis,
gastroduodenal ulcers and gastric carcinoma. Thus, the eradication of H. pylori infection is …

Ursolic acid (UA), which has many biological properties such as anti-cancer, anti-
inflammatory and antioxidant, and regulates some pharmacological processes, has been …

New anthraquinone derivatives acruciquinones A–C (1–3), together with ten known
metabolites, were isolated from the obligate marine fungus Asteromyces cruciatus KMM …

Blocking the catalytic activity of urease has been shown to have a key role in different
diseases as well as in different agricultural applications. A vast array of molecules have …

Urease has a long and distinguished history in the development of enzymology since it was
the first enzyme crystallized by Sumner in 1926. The present review article is focused on the …

Twenty-six Biginelli adducts were synthesized through an ionic liquid-assisted synthesis
with up to 92% yield. Sixteen of these Biginelli adducts were then assayed to determine their …

Urease is a metalloenzyme that catalyzes the hydrolysis of urea into ammonia and carbon
dioxide, which has a negative impact on human health and agriculture. In this study, the …

In the current study, pyroglutamic acid (pGlu), a natural amino acid derivative, has efficiently
inhibited the catalytic activities of three important enzymes, namely: Human recombinant …

Helicobacter pylori-induced ulcers and gastric cancer have been one of the main obstacles
that the human community has ever struggled with, especially in recent decades. Several …

A new series of metronidazole-1, 2, 3-triazole derivatives 6a–o was synthesized and
evaluated as Helicobacter pylori urease inhibitors. All the synthesized compounds were …