Nervous systems evolved to effectively navigate the dynamics of the environment to achieve
their goals. One framework used to study this fundamental problem arose in the study of …

Norepinephrine (NE) is synthesized in the Locus Coeruleus (LC) of the brainstem, from
where it is released by axonal varicosities throughout the brain via volume transmission. A …

Cortical spreading depression (CSD) is thought to be a neuronal mechanism that expands
the penumbra zone after focal brain ischemia and that causes migraine aura. Both …

Rationale Stressful life experiences facilitate responsiveness to psychostimulant drugs.
While there is ample evidence that adrenal glucocorticoids mediate these effects of stress …

The present study investigated the role of alpha2A‐adrenoceptor (α2A‐AR) subtype in the
regulation of noradrenaline (NA) and dopamine (DA) release in the nucleus accumbens …

The prelimbic region of the medial prefrontal cortex (mPFC) is a brain area crucial for
memory, attention, and decision making. It has been shown that α2-adreneoceptors (α2 …

We report the discovery of a new family of α2 adrenergic receptor antagonists derived from
atipamezole. Affinities of the compounds at human α2 and α1b receptors as well as their …

Reversal learning depends on cognitive flexibility. Many reversal learning studies assess
cognitive flexibility based on the number of reversals that occur over a test session …

Introduction: The re-establishment of electrode position after microiontophoresis with multi-
barrelled electrodes has always been a complicated and mostly inaccurate procedure. The …

Recent studies have established that one-trial-back decision policies (Win-Stay/Lose-Shift)
and measures of reinforcement learning (RL), eg learning rate, can explain how animals …