Chronic diabetic wounds represent a huge socioeconomic burden for both affected
individuals and the entire healthcare system. Although the number of available treatment …

Significance: The incidence of chronic wounds is increasing due to our aging population
and the augment of people afflicted with diabetes. With the extended knowledge on the …

The purpose of this study was to permit bone marrow mesenchymal stem cells (BMSCs) to
reach their full potential in the treatment of chronic wounds. A biocompatible multifunctional …

There is a clinical need for new, more effective treatments for chronic wounds in diabetic
patients. Lack of epithelial cell migration is a hallmark of nonhealing wounds, and diabetes …

Significance: Postnatal vasculogenesis mediated via endothelial progenitor cells (EPCs)
contributes to re-endothelialization and augments neovascularization after ischemia and …

Nanofibrous scaffolds are artificial extracellular matrices which provide natural environment
for tissue formation. In comparison to other forms of scaffolds, the nanofibrous scaffolds …

The significant clinical challenge presented by diabetic wounds is due to their impaired
healing process and increased risk of complications. It is estimated that a foot ulcer will …

Deficient angiogenesis is the major abnormality impairing the healing process of diabetic
wounds. Electrospun nanofiber membranes have shown promise for wound dressing. A …

Tissue engineering (TE) and regenerative medicine are a blend of developmental biology,
life sciences, and engineering efforts that attempts to address clinical problems. Tissue …

Endothelial progenitor cells (EPCs) contribute to de novo angiogenesis, tissue regeneration,
and remodeling. Interleukin 10 (IL‐10), an anti‐inflammatory cytokine that primarily signals …