Neurodegenerative diseases pose a substantial socioeconomic burden on society.
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …

Amyotrophic lateral sclerosis (ALS) has historically posed unique challenges for gene-
therapy-based approaches, due to a paucity of therapeutic targets as well as the difficulty of …

Fractalkine (FKN, CX3CL1) is a transmembrane chemokine expressed by neurons in the
central nervous system (CNS). CX3CL1 signals through its unique receptor, CX3CR1, that is …

Neuroinflammation was initially thought of as a consequence of neurodegenerative disease
pathology, but more recently it is becoming clear that it plays a significant role in the …

Reactive oxygen species (ROS) are chemically reactive molecules that are naturally
produced within biological systems. Research has focused extensively on revealing the …

Brain tissue has a remarkable ability to accumulate glutamate. This ability is due to
glutamate transporter proteins present in the plasma membranes of both glial cells and …

Abstract Amyotrophic Lateral Sclerosis (ALS) is a motor neuron disease affecting upper and
lower motor neurons in the central nervous system. Patients with ALS develop extensive …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the
death of both upper and lower motor neurons (MNs) in the brain, brainstem and spinal cord …

Amyotrophic lateral sclerosis is a late-onset progressive neurodegenerative disease
affecting motor neurons. The etiology of most ALS cases remains unknown, but 2% of …

Neurodegenerative disorders are characterized by extensive neuron death that leads to
functional decline, but the neurobiological correlates of functional decline in normal aging …