Atherosclerosis is the main risk factor for cardiovascular disease (CVD), which is the leading
cause of mortality worldwide. Atherosclerosis is initiated by endothelium activation and …

Oxidative stress plays a key role in many physiological and pathological conditions. The
intracellular oxidative homeostasis is tightly regulated by the reactive oxygen species …

Atherosclerosis underlies the predominant number of cardiovascular diseases and remains
a leading cause of morbidity and mortality worldwide. The development, progression and …

MicroRNA (miRNA) have gained widespread attention for their role in diverse vascular
processes including angiogenesis, apoptosis, proliferation, and migration. Despite great …

The mammalian genome is transcribed in a developmentally regulated manner, generating
RNA strands ranging from long to short non-coding RNA (ncRNAs). NcRNAs generated by …

MicroRNAs are short noncoding RNAs, expressed in humans and involved in sequence-
specific post-transcriptional regulation of gene expression. They have emerged as key …

Atherosclerotic cardiovascular disease (ASCVD) proceeds through a series of stages:
initiation, progression (or regression), and complications. By integrating known biology …

Atherosclerosis is a complex multifactorial disease that, despite advances in lifestyle
management and drug therapy, remains to be the major cause of high morbidity and …

Rationale: In the microenvironment of atherosclerotic lesions, vascular smooth muscle cells
(vSMCs) switch to a dedifferentiated state but the underlying molecular mechanisms driving …

Context: Type 2 diabetes is a chronic disease characterized by inadequate β-cell response
to the progressive insulin resistance. MicroRNAs (miRNAs) are short, endogenous …