Being the largest internal organ of the human body with the unique ability of self-
regeneration, the liver is involved in a wide variety of vital functions that require highly …

Hepatitis C virus (HCV) is an important human pathogen that causes hepatitis, liver cirrhosis
and hepatocellular carcinoma. It imposes a serious problem to public health in the world as …

Apolipoprotein C1 (apoC1), the smallest of all apolipoproteins, participates in lipid transport
and metabolism. In humans, APOC1 gene is in linkage disequilibrium with APOE gene on …

Hepatitis C virus (HCV) is a major global health burden accounting for around 170 million
chronic infections worldwide. Although highly potent direct-acting antiviral drugs to treat …

Apolipoprotein E (ApoE) is a multifunctional protein critical for lipid metabolism and
cholesterol homeostasis. In addition to being a well-known genetic determinant of both …

Hepatitis C Virus (HCV) infects over 150 million people worldwide. In most cases HCV
infection becomes chronic, causing liver disease ranging from fibrosis to cirrhosis and …

Acyl-CoA: glycerol-3-phosphate acyltransferase (GPAT) and acyl-CoA: 1-acyl-glycerol-3-
phosphate acyltransferase (AGPAT) are involved in the de novo synthesis of triacylglycerol …

Hepatitis C virus (HCV) is an enveloped, positive strand RNA virus classified within the
Flaviviridae family and is a major cause of liver disease worldwide. HCV life cycle and …

The assembly of infectious hepatitis C virus (HCV) particles is tightly linked to components of
the very-low-density lipoprotein (VLDL) pathway. We and others have shown that …

Hepatitis C virus (HCV) causes serious liver disease in chronically infected individuals.
Infectious virions are released from hepatocytes as lipoprotein complexes, indicating that the …