Kidney-on-a-chip technology for drug-induced nephrotoxicity screening
Improved model systems to predict drug efficacy, interactions, and drug-induced kidney
injury (DIKI) are crucially needed in drug development. Organ-on-a-chip technology is a …
injury (DIKI) are crucially needed in drug development. Organ-on-a-chip technology is a …
Drug-Induced Nephrotoxicity: Clinical Impact and Preclinical in Vitro Models
The kidney is a major target for drug-induced toxicity. Drug-induced nephrotoxicity remains a
major problem in the clinical setting, where the use of nephrotoxic drugs is often …
major problem in the clinical setting, where the use of nephrotoxic drugs is often …
Organ-on-a-chip: A new tool for in vitro research
Abstract Organ-on-a-chip (OOC, organ chip) technology can closely simulate the human
microenvironment, synthesize organ-like functional units on a fluidic chip substrate, and …
microenvironment, synthesize organ-like functional units on a fluidic chip substrate, and …
A quantitative approach to screen for nephrotoxic compounds in vitro
Nephrotoxicity due to drugs and environmental chemicals accounts for significant patient
mortality and morbidity, but there is no high throughput in vitro method for predictive …
mortality and morbidity, but there is no high throughput in vitro method for predictive …
Organotypic and microphysiological human tissue models for drug discovery and development—current state-of-the-art and future perspectives
The number of successful drug development projects has been stagnant for decades
despite major breakthroughs in chemistry, molecular biology, and genetics. Unreliable target …
despite major breakthroughs in chemistry, molecular biology, and genetics. Unreliable target …
Prediction of drug-induced nephrotoxicity and injury mechanisms with human induced pluripotent stem cell-derived cells and machine learning methods
The renal proximal tubule is a main target for drug-induced toxicity. The prediction of
proximal tubular toxicity during drug development remains difficult. Any in vitro methods …
proximal tubular toxicity during drug development remains difficult. Any in vitro methods …
Tissue culture models of AKI: from tubule cells to human kidney organoids
J Bejoy, ES Qian, LE Woodard - Journal of the American Society of …, 2022 - journals.lww.com
AKI affects approximately 13.3 million people around the world each year, causing CKD
and/or mortality. The mammalian kidney cannot generate new nephrons after postnatal …
and/or mortality. The mammalian kidney cannot generate new nephrons after postnatal …
3-D human renal tubular organoids generated from urine-derived stem cells for nephrotoxicity screening
H Guo, N Deng, L Dou, H Ding, T Criswell… - ACS biomaterials …, 2020 - ACS Publications
The development of human cell-based systems to replace the use of rodents or the two-
dimensional culture of cells for studying nephrotoxicity is urgently needed. Human urine …
dimensional culture of cells for studying nephrotoxicity is urgently needed. Human urine …
High-throughput imaging-based nephrotoxicity prediction for xenobiotics with diverse chemical structures
The kidney is a major target for xenobiotics, which include drugs, industrial chemicals,
environmental toxicants and other compounds. Accurate methods for screening large …
environmental toxicants and other compounds. Accurate methods for screening large …