Kidney fibrosis, characterized by excessive deposition of extracellular matrix (ECM) that
leads to tissue scarring, is the final common outcome of a wide variety of chronic kidney …

Chronic kidney disease (CKD) is a devastating condition that is reaching epidemic levels
owing to the increasing prevalence of diabetes mellitus, hypertension and obesity, as well …

Renal tubules are the major component of the kidney and are vulnerable to a variety of
injuries including hypoxia, proteinuria, toxins, metabolic disorders, and senescence. It has …

Diabetes induces the onset and progression of renal injury through causing hemodynamic
dysregulation along with abnormal morphological and functional nephron changes. The …

The pathologic paradigm for renal progression is advancing tubulointerstitial fibrosis.
Whereas mechanisms underlying fibrogenesis have grown in scope and understanding in …

Members of the CCN family of matricellular proteins are crucial for embryonic development
and have important roles in inflammation, wound healing and injury repair in adulthood …

Renal tissue injury initiates inflammatory and fibrotic processes that occur to promote
regeneration and repair. After renal injury, damaged tissue releases cytokines and …

Chronic kidney disease (CKD) is characterized by persistent inflammation and progressive
fibrosis, ultimately leading to end‐stage renal disease. Although many studies have …

Background Glomerulonephritis, which causes inflammation in glomeruli, is a common
cause of end-stage renal failure. Severe and prolonged inflammation can damage glomeruli …

The main function of chemokines is to guide inflammatory cells in their migration to sites of
inflammation. During the last 2 decades, an expanding number of chemokines and their …