Cells and tissues generate and are exposed to various mechanical forces that act across a
range of scales, from tissues to cells to organelles. Forces provide crucial signals to inform …

Protein and DNA have been considered as the major components of chromatin. But beyond
that, an increasing number of studies show that RNA occupies a large amount of chromatin …

Extensive 3D folding is required to package a genome into the tiny nuclear space, and this
packaging must be compatible with proper gene expression. Thus, in the well-hierarchized …

Abstract During transcription, RNA Polymerase II (RNAPII) is spatially organised within the
nucleus into clusters that correlate with transcription activity. While this is a hallmark of …

In eukaryotic cells, the nucleus houses the genomic material of the cell. The physical
properties of the nucleus and its ability to sense external mechanical cues are tightly linked …

Myosin VI (MVI) has been found to be overexpressed in ovarian, breast and prostate
cancers. Moreover, it has been shown to play a role in regulating cell proliferation and …

Natural killer (NK) cells were previously considered to represent short-lived, innate
lymphocytes. However, mouse models have revealed expansion and persistence of …

In mammals, homologous chromosomes rarely pair outside meiosis. One exception is the X
chromosome, which transiently pairs during X-chromosome inactivation (XCI). How two …

The importance of myosin motor protein is well-characterised within the cytoplasm and
cytoskeleton. However, mounting evidence on four nuclear myosins highlights the central …

Myosin VI is critical for cargo trafficking and sorting during early endocytosis and
autophagosome maturation, and abnormalities in these processes are linked to cancers …