Telomere maintenance via telomerase reactivation is a nearly universal hallmark of cancer
cells which enables replicative immortality. In contrast, telomerase activity is silenced in most …

Background Limitless self-renewal is one of the hallmarks of cancer and is attained by
telomere maintenance, essentially through telomerase (h TERT) activation. Transcriptional …

Telomere repeats at chromosomal ends, critical to genome integrity, are maintained through
an elaborate network of proteins and pathways. Shelterin complex proteins shield telomeres …

Telomeres, the protective structures of chromosome ends are gradually shortened by each
cell division, eventually leading to senescence or apoptosis. Cancer cells maintain the …

Mutations in the promoter of human telomerase reverse transcriptase (hTERT) result in
hyperactivation of hTERT. Notably, all mutations are G> A transitions, frequently found in a …

Telomerase is expressed in more than 85% of cancer cells. Tumor cells with metastatic
potential may have a high telomerase activity, allowing cells to escape from the inhibition of …

Evasion of replicative senescence and proliferation without restriction, sometimes
designated as immortalisation, is one of the hallmarks of cancer that may be attained …

Targeted therapies revolutionized the management of patients with advanced and
metastatic cutaneous melanoma. However, despite recent advances in the understanding of …

Although activating BRAF/NRAS mutations are frequently seen in melanomas, they are not
sufficient to drive malignant transformation and require additional events. Frequent co …

Synergistic effects of BRAF V600E and TERT promoter mutations on the poor clinical
outcomes in papillary thyroid cancer (PTC) have been demonstrated. The potential …