To accommodate daily recurring environmental changes, animals show cyclic variations in
behaviour and physiology, which include prominent behavioural states such as sleep–wake …

Hypoxia, characterized by reduced oxygen concentration, is a significant stressor that affects
the survival of aerobic species and plays a prominent role in cardiovascular diseases. From …

The occurrence and sequelae of disorders that lead to hypoxic spells such as asthma,
chronic obstructive pulmonary disease, and obstructive sleep apnea (OSA) exhibit daily …

Emerging evidences show that dysregulation of circadian genes is closely associated with
tumorigenesis. However, whether circadian genes regulate the reprogramming of …

Oxygen maintains the homeostasis of an organism in a delicate balance in different tissues
and organs. Under hypoxic conditions, hypoxia-inducible factors (HIFs) are specific and …

Circadian rhythms significantly affect metabolism, and their disruption leads to
cardiometabolic diseases and fibrosis. The clock repressor Rev-Erb is mainly expressed in …

Summary The Qinghai-Tibet Plateau (QTP) harbors hundreds of species well adapted to its
extreme conditions, including its low-oxygen (hypoxic) atmosphere. Here, we show that the …

Prenatal hypoxia during the prenatal period can interfere with the developmental trajectory
and lead to developing hypertension in adulthood. Prenatal hypoxia is often associated with …

Obstructive sleep apnea is the most common sleep‐related breathing disorder worldwide
and remains underdiagnosed. Its multiple associated comorbidities contribute to a …

Humans have internal circadian clocks that ensure that important physiological functions
occur at specific times of the day. These molecular clocks are regulated at the genomic level …