The genomes of influenza viruses consist of multiple segments of single-stranded negative-
sense RNA. Each of these segments is bound by the heterotrimeric viral RNA-dependent …

Fifty years after the discovery of the mouse Mx1 gene, researchers are still trying to
understand the molecular details of the antiviral mechanisms mediated by Mx proteins. Mx …

Abstract Influenza A Virus (IAV) is a recurring respiratory virus with limited availability of
antiviral therapies. Understanding host proteins essential for IAV infection can identify …

Proteins in the karyopherin-β family mediate the majority of macromolecular transport
between the nucleus and the cytoplasm. Eleven of the 19 known human karyopherin-βs and …

Organisms are constantly exposed to microbial pathogens in their environments. When a
pathogen meets its host, a series of intricate intracellular interactions shape the outcome of …

The goal of a virus particle is to transport its genome in a replication-competent form from an
infected cell to an uninfected cell. To enter a new host cell, the majority of viruses take …

Influenza virus is a segmented, negative strand RNA virus with each genome segment being
packaged in a distinct ribonucleoprotein particle (RNP). The RNP consists of the …

Influenza viruses cause epidemics and pandemics. Like all viruses, influenza viruses rely on
the host cellular machinery to support their life cycle. Accordingly, identification of the host …

In recent decades, several viruses have resulted in large outbreaks with serious health,
economic and social consequences. The current unprecedented outbreak of the new …

Mx1 is a GTPase that is part of the antiviral response induced by type I and type III
interferons in the infected host. It inhibits influenza virus infection by blocking viral …