Iron is an essential nutrient that facilitates cell proliferation and growth. However, iron also
has the capacity to engage in redox cycling and free radical formation. Therefore, iron can …

In many organisms, the methylation of cytosine in DNA has a key role in silencing'parasitic'
DNA elements, regulating transcription and establishing cellular identity. The recent …

Hydroxymethylcytosine (5hmC) is an important mammalian DNA epigenetic modification
that has been linked to gene regulation and cancer pathogenesis. Here we explored the …

Adverse outcome pathways (AOPs) organize knowledge on the progression of toxicity
through levels of biological organization. By determining the linkages between toxicity …

Background The DNA methylation profiles of mammalian cell lines differ from those of the
primary tissues from which they were derived, exhibiting increasing divergence from the in …

Simple Summary Liquid biopsies provide a non-invasive means to diagnose and profile
tumors when tissue is not available. Sequence-based analysis of cell-free DNA (cfDNA) is …

The patterns of DNA methylation in human cancer cells are highly abnormal and often
involve the acquisition of DNA hypermethylation at hundreds or thousands of CpG islands …

The viability of any species requires that the genome is kept stable as it is transmitted from
generation to generation by the germ cells. One of the challenges to transgenerational …

Non-small-cell lung cancer (NSCLC), the most common type of lung cancer accounting for
85% of the cases, is often diagnosed at advanced stages owing to the lack of efficient early …

Aberrant hypermethylation of CpG islands (CGI) in human tumors occurs predominantly at
repressed genes in the host tissue, but the preceding events driving this phenomenon are …