Tau protein is involved in various cellular processes, including having a canonical role in
binding and stabilization of microtubules in neurons. Tauopathies are neurodegenerative …

BACKGROUND Neurons are polarized cells with extreme geometries. Multiple dendrites
and one axon generally emerge from a single cell body and establish synaptic contacts with …

Non-centrosomal microtubule bundles play important roles in cellular organization and
function. Although many diverse proteins are known that can bundle microtubules …

Tau protein aggregation into neurofibrillary tangles in the central nervous system contributes
to the etiology of certain neurodegenerative disorders, including Alzheimer's disease (AD) …

Microtubules (MT) and actin microfilaments are dynamic cytoskeleton components involved
in a range of intracellular processes. MTs play a role in cell division, beating of cilia and …

The motor proteins kinesin and dynein transport organelles, mRNA, proteins, and signaling
molecules along the microtubule cytoskeleton. In addition to serving as tracks for transport …

Axons are the slender, cable-like, up to meter-long projections of neurons that electrically
wire our brains and bodies. In spite of their challenging morphology, they usually need to be …

In neurons, microtubule networks alternate between single filaments and bundled arrays
under the influence of effectors controlling their dynamics and organization. Tau is a …

Tau pathology is associated with cognitive decline in Alzheimer's disease, and missense tau
mutations cause frontotemporal dementia. Hyperphosphorylation and misfolding of tau are …

The axon-initial-segment (AIS) of mature neurons contains microtubule (MT) fascicles (linear
bundles) implicated as retrograde diffusion barriers in the retention of MT-associated protein …