RecQ helicases are an important family of genome surveillance proteins conserved from
bacteria to humans. Each of the five human RecQ helicases plays critical roles in genome …

Werner syndrome (WS) is a prototypical segmental progeroid syndrome characterized by
multiple features consistent with accelerated aging. It is caused by null mutations of the …

Accurate processing of stalled or damaged DNA replication forks is paramount to genomic
integrity and recent work points to replication fork reversal and restart as a central …

Helicases have major roles in genome maintenance by unwinding structured nucleic acids.
Their prominence is marked by various cancers and genetic disorders that are linked to …

Single-molecule analyses of DNA replication have greatly advanced our understanding of
mammalian replication restart. Several proteins that are not part of the core replication …

Age-related degenerative and malignant diseases represent major challenges for health
care systems. Elucidation of the molecular mechanisms underlying carcinogenesis and age …

Damaged DNA templates provide an obstacle to the replication fork and can cause genome
instability. In eukaryotes, tolerance to damaged DNA is mediated largely by the RAD6 …

Since the discovery of the DNA double helix, there has been a fascination in understanding
the molecular mechanisms and cellular processes that account for:(i) the transmission of …

Faithful duplication of genetic material during every cell division is essential to ensure
accurate transmission of genetic information to daughter cells. DNA helicases play a crucial …

Modulation of DNA repair proteins by small molecules has attracted great interest. An in vitro
helicase activity screen was used to identify molecules that modulate DNA unwinding by …