In precision oncology, two major strategies are being pursued for predicting clinically
relevant tumour behaviours, such as treatment response and emergence of drug resistance …

Epithelial–mesenchymal transition (EMT) has been implicated in various aspects of tumor
development, including tumor invasion and metastasis, cancer stemness, and therapy …

Gene fusions represent an important class of somatic alterations in cancer. We
systematically investigated fusions in 9,624 tumors across 33 cancer types using multiple …

Target-based drug discovery is the dominant paradigm of drug discovery; however, a
comprehensive evaluation of its real-world efficiency is lacking. Here, a manual systematic …

Resistance to BRAF/MEK inhibitor therapy in BRAFV600‐mutated advanced melanoma
remains a major obstacle that limits patient benefit. Microenvironment components including …

Animals as model organisms, the silent sentinels, stand watch over the environmental health
of the world. These are non-human animal species which can be used to understand …

Skin cancer, which includes melanoma and squamous cell carcinoma, represents the most
common type of cutaneous malignancy worldwide, and its incidence is expected to rise in …

Recently, the zebrafish has been established as one of the most important model organisms
for medical research. Several studies have proved that there is a high level of similarity …

Discoidin domain receptors, DDR1 and DDR2, are two members of collagen receptor family
that belong to tyrosine kinase receptor subgroup. Unlike other matrix receptor-like integrins …

Dasatinib, a multikinase inhibitor, is used in the treatment of chronic myeloid leukemia and
was developed to overcome imatinib resistance. Its mechanism of action involves the …