The UK Medical Research Council's widely used guidance for developing and evaluating
complex interventions has been replaced by a new framework, commissioned jointly by the …

Clinical research is an alternative terminology used to describe medical research. Clinical
research involves people, and it is generally carried out to evaluate the efficacy of a …

Recent FDA guidance on adaptive clinical trial designs defines bias as “a systematic
tendency for the estimate of treatment effect to deviate from its true value,” and states that it is …

While interest in the application of machine learning to improve healthcare has grown
tremendously in recent years, a number of barriers prevent deployment in medical practice …

Evidence-based nutritional recommendations address the health impact of suboptimal
nutritional status. Efficacy randomized controlled trials (RCTs) have traditionally been the …

It has been 100 years since the life-saving discovery of insulin, yet daily management of type
1 diabetes (T1D) remains challenging. Even with closed-loop systems, the prevailing need …

The landscape of cancer therapy has been transformed by advances in clinical next‐
generation sequencing, genomically targeted therapies, and immunotherapies. Well …

Abstract Background and Objectives Adaptive features may increase flexibility and efficiency
of clinical trials, and improve participants' chances of being allocated to better interventions …

Fundamentals of Medical Ethics — A New Perspective Series | New England Journal of Medicine
Skip to main content The New England Journal of Medicine homepage Advanced Search …

Background For medical conditions with numerous interventions worthy of investigation,
there are many advantages of a multi-arm multi-stage (MAMS) platform trial approach …