Abstract Background Receptor tyrosine kinases (RTKs) are signaling enzymes responsible
for the transfer of Adenosine triphosphate (ATP) γ-phosphate to the tyrosine residues …

Searching for targets that allow pharmacological inhibition of cell proliferation in over-
proliferative states, such as cancer, leads us to finely understand the complex mechanisms …

Background. The main reason for dose reduction of afatinib is gastrointestinal toxicity (GT).
In a phase II study, we analyzed anthropometrical, nutritional, and biochemical factors …

Tyrosine kinases are known to play a role in tumour growth and proliferation, and they have
become common drug targets. Tyrosine kinase inhibitors (TKIs) prohibit associated kinases …

Background: Vascular endothelial growth factor (VEGF) has an essential role in tumor
metastasis by inducing the construction of abnormal blood vessels. Epidermal growth factor …

Non-small cell lung cancer (NSCLC) remains the leading cause of cancer-related deaths. In
the last decade, the epidermal growth factor receptor (EGFR) signalling pathway has …

Commonly observed aberrations in epidermal growth factor receptor (EGFR) signaling have
led to the development of EGFR-targeted therapies for various cancers, including non–small …

Novel concepts and understanding of receptors lead to discoveries and optimization of
many small molecules and antibodies as anti-cancerous drugs. Receptor tyrosine kinases …

Over one third of patients who have undergone oral squamous cell carcinoma (OSCC)
surgical resections develop life-threatening and often untreatable recurrences. A variety of …

The development of resistance to therapy continues to be a serious clinical problem in lung
cancer management. Epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) …