In order to meet the high energy demand, a metabolic reprogramming occurs in cancer cells.
Its role is crucial in promoting tumor survival. Among the substrates in demand, oxygen is …

The purpose of this review is to summarize the research progress of PI3K/Akt signaling
pathway in erythropoiesis and glycolysis. Phosphatidylinositol‑4, 5‑bisphosphate 3‑kinase …

Introduction: Hypoxia is one of the intrinsic features of solid tumors, and it is always
associated with aggressive phenotypes, including resistance to radiation and …

Studies of the regulation of erythropoietin (EPO) production by the liver and kidneys, one of
the classical physiological responses to hypoxia, led to the discovery of human oxygen …

The cardiovascular system ensures the delivery of oxygen and nutrients to all cells, tissues,
and organs. Under extended exposure to reduced oxygen levels, cells are able to survive …

Hypoxia-inducible factors (HIFs) control transcriptional responses to reduced O2 availability.
HIFs are heterodimeric proteins composed of an O2-regulated HIF-α subunit and a …

Intervertebral disc degeneration (IDD) is the primary pathological mechanism that underlies
low back pain. Overloading-induced cell death, especially endogenous stem cell death, is …

The cellular response to oxygen deprivation is governed largely by a family of transcription
factors known as Hypoxia Inducible Factors (HIFs). This review focuses on the molecular …

The vascular network delivers oxygen (O2) and nutrients to all cells within the body. It is
therefore not surprising that O2 availability serves as a primary regulator of this complex …

Clear cell renal cell carcinoma (ccRCC), the most common form of kidney cancer, is
characterized by elevated glycogen levels and fat deposition. These consistent metabolic …