Tissue and organ development during embryogenesis relies on the collective and
coordinated action of many cells. Recent studies have revealed that tissue material …

The development of the vertebrate body axis relies on the activity of different populations of
axial progenitors, including neuromesodermal progenitors. Currently, the term …

Integrated in vitro models of human organogenesis are needed to elucidate the multi-
systemic events underlying development and disease. Here we report the generation of …

The ability of tissues and cells to move and rearrange is central to a broad range of diverse
biological processes such as tissue remodeling and rearrangement in embryogenesis, cell …

Increasing evidence demonstrates that mechanical forces, in addition to soluble molecules,
impact cell and tissue functions in physiology and diseases. How living cells integrate …

Tissues undergoing morphogenesis impose mechanical effects on one another. How
developmental programs adapt to or take advantage of these effects remains poorly …

Embryonic stem cell cultures are thought to self-organize into embryoid bodies, able to
undergo symmetry-breaking, germ layer specification and even morphogenesis. Yet, it is …

The neural tube is an important model system of morphogenesis representing the
developmental module of out-of-plane epithelial deformation. As the embryonic precursor of …

Morphogenesis is governed by the interplay of molecular signals and mechanical forces
across multiple length scales. The last decade has seen tremendous advances in our …

Gastruloids have emerged as highly useful in vitro models of mammalian gastrulation. One
of the most striking features of 3D gastruloids is their elongation, which mimics the extension …