[PDF][PDF] Germinal center B cell dynamics
L Mesin, J Ersching, GD Victora - Immunity, 2016 - cell.com
Germinal centers (GCs) are the site of antibody diversification and affinity maturation and as
such are vitally important for humoral immunity. The study of GC biology has undergone a …
such are vitally important for humoral immunity. The study of GC biology has undergone a …
Extrafollicular responses in humans and SLE
SA Jenks, KS Cashman, MC Woodruff… - Immunological …, 2019 - Wiley Online Library
Chronic autoimmune diseases, and in particular Systemic Lupus Erythematosus (SLE), are
endowed with a long‐standing autoreactive B‐cell compartment that is presumed to …
endowed with a long‐standing autoreactive B‐cell compartment that is presumed to …
Nanoparticle size influences antigen retention and presentation in lymph node follicles for humoral immunity
Lymph node follicles capture and retain antigens to induce germinal centers and long-lived
humoral immunity. However, control over antigen retention has been limited. Here we …
humoral immunity. However, control over antigen retention has been limited. Here we …
Complement system in neural synapse elimination in development and disease
J Presumey, AR Bialas, MC Carroll - Advances in immunology, 2017 - Elsevier
Recent discoveries implicate the classical complement cascade in normal brain
development and in disease. Complement proteins C1q, C3, and C4 participate in synapse …
development and in disease. Complement proteins C1q, C3, and C4 participate in synapse …
Taming lupus—a new understanding of pathogenesis is leading to clinical advances
Z Liu, A Davidson - Nature medicine, 2012 - nature.com
Systemic lupus erythematosus (SLE) is an autoimmune disease that is characterized by the
loss of tolerance to nuclear self antigens, the production of pathogenic autoantibodies and …
loss of tolerance to nuclear self antigens, the production of pathogenic autoantibodies and …
[PDF][PDF] A blueprint for HIV vaccine discovery
Despite numerous attempts over many years to develop an HIV vaccine based on classical
strategies, none has convincingly succeeded to date. A number of approaches are being …
strategies, none has convincingly succeeded to date. A number of approaches are being …
[PDF][PDF] Regulation of humoral immunity by complement
MC Carroll, DE Isenman - Immunity, 2012 - cell.com
The complement system of innate immunity is important in regulating humoral immunity
largely through the complement receptor CR2, which forms a coreceptor on B cells during …
largely through the complement receptor CR2, which forms a coreceptor on B cells during …
[HTML][HTML] Delivery of nanovaccine towards lymphoid organs: recent strategies in enhancing cancer immunotherapy
With the in-depth exploration on cancer therapeutic nanovaccines, increasing evidence
shows that the poor delivery of nanovaccines to lymphoid organs has become the culprit …
shows that the poor delivery of nanovaccines to lymphoid organs has become the culprit …
[HTML][HTML] B cell homeostasis and follicle confines are governed by fibroblastic reticular cells
Fibroblastic reticular cells (FRCs) are known to inhabit T cell–rich areas of lymphoid organs,
where they function to facilitate interactions between T cells and dendritic cells. However, in …
where they function to facilitate interactions between T cells and dendritic cells. However, in …