Heterochromatin is characterized by dimethylated or trimethylated histone H3 Lys9
(H3K9me2 or H3K9me3, respectively) and is found at transposable elements, satellite …

BACKGROUND The eukaryotic genome is hierarchically organized in the cell nucleus into
DNA loops, chromatin domains, compartments, and, ultimately, chromosomes. Many of the …

Olfactory receptors (ORs) are not exclusively expressed in the olfactory sensory neurons;
they are also observed outside of the olfactory system in all other human tissues tested to …

Simple Summary Our manuscript summarizes the up-to-date data on the complex and
dynamic nature of adaptation mechanisms and evolutionary processes taking place during …

The sense of smell collects vital information about the environment by detecting a multitude
of chemical odorants. Breadth and sensitivity are provided by a huge number of …

The monogenic and monoallelic expression of only one out of> 1000 mouse olfactory
receptor (ORs) genes requires the formation of large heterochromatic chromatin domains …

Dominance is a basic property of inheritance systems describing the link between a diploid
genotype at a single locus and the resulting phenotype. Models for the evolution of …

Background: Correct gene expression programming of the cardiomyocyte underlies the
normal functioning of the heart. Alterations to this can lead to the loss of cardiac …

Disruption of chromatin structure due to epimutations is a leading genetic etiology of
neurodevelopmental disorders, collectively known as chromatinopathies. We show that …

The mammalian genome possesses> 2000 olfactory receptor (OR) alleles regulated by 63
known OR-Enhancer elements, yet each olfactory sensory neuron (OSN) expresses only a …