Novel treatment approaches are needed to overcome innate and acquired mechanisms of
resistance to current anticancer therapies in cancer cells and the tumour immune …

Breast cancer (BC) is the main cause of cancer-related mortality among women globally.
Despite substantial advances in the identification and management of primary tumors …

Liver metastasis is a major cause of death in patients with colorectal cancer (CRC). Fatty
liver promotes liver metastasis, but the underlying mechanism remains unclear. We …

Efferocytosis inhibition is emerging as an attractive strategy for antitumor immune therapy
because of the subsequent leak of abundant immunogenic contents. However, the practical …

Anti-HER2 therapies have markedly improved prognosis of HER2-positive breast cancer.
However, different mechanisms play a role in treatment resistance. Here, we identified AXL …

The failure of chemotherapy is a major challenge nowadays, and in order to ensure effective
treatment of cancer patients, it is of great importance to reveal the molecular pathways and …

The Janus kinase–signal transducer and activator of transcription (JAK–STAT) pathway is
involved in many immunological processes, including cell growth, proliferation …

As one of the most abundant immune cell populations in the tumor microenvironment (TME),
tumor‐associated macrophages (TAMs) play important roles in multiple solid malignancies …

Pancreatic ductal adenocarcinoma is a highly metastatic disease and macrophages support
liver metastases. Efferocytosis, or engulfment of apoptotic cells by macrophages, is an …

Macrophage-targeting therapies have become attractive strategies for immunotherapy.
Deficiency of MARCO significantly inhibits tumor progression and metastasis in murine …