Structure and function of IP3 receptors
Inositol 1, 4, 5-trisphosphate receptors (IP3Rs), by releasing Ca2+ from the endoplasmic
reticulum (ER) of animal cells, allow Ca2+ to be redistributed from the ER to the cytosol or …
reticulum (ER) of animal cells, allow Ca2+ to be redistributed from the ER to the cytosol or …
Modulation of Ca2+ signaling by antiapoptotic Bcl-2 versus Bcl-xL: from molecular mechanisms to relevance for cancer cell survival
N Rosa, F Speelman-Rooms, JB Parys… - Biochimica et Biophysica …, 2022 - Elsevier
Members of the Bcl-2-protein family are key controllers of apoptotic cell death. The family is
divided into antiapoptotic (including Bcl-2 itself, Bcl-xL, Mcl-1, etc.) and proapoptotic …
divided into antiapoptotic (including Bcl-2 itself, Bcl-xL, Mcl-1, etc.) and proapoptotic …
Defining the stoichiometry of inositol 1,4,5-trisphosphate binding required to initiate Ca2+ release
KJ Alzayady, L Wang, R Chandrasekhar… - Science …, 2016 - science.org
Inositol 1, 4, 5-trisphosphate (IP3) receptors (IP3Rs) are tetrameric intracellular Ca2+-
release channels with each subunit containing a binding site for IP3 in the amino terminus …
release channels with each subunit containing a binding site for IP3 in the amino terminus …
Origins of eukaryotic excitability
All living cells interact dynamically with a constantly changing world. Eukaryotes, in
particular, evolved radically new ways to sense and react to their environment. These …
particular, evolved radically new ways to sense and react to their environment. These …
Simulation of calcium signaling in fine astrocytic processes: Effect of spatial properties on spontaneous activity
Astrocytes, a glial cell type of the central nervous system, have emerged as detectors and
regulators of neuronal information processing. Astrocyte excitability resides in transient …
regulators of neuronal information processing. Astrocyte excitability resides in transient …
Functional determination of calcium-binding sites required for the activation of inositol 1, 4, 5-trisphosphate receptors
V Arige, LE Terry, LE Wagner, S Malik… - Proceedings of the …, 2022 - National Acad Sciences
Inositol 1, 4, 5-trisphosphate receptors (IP3Rs) initiate a diverse array of physiological
responses by carefully orchestrating intracellular calcium (Ca2+) signals in response to …
responses by carefully orchestrating intracellular calcium (Ca2+) signals in response to …
CRISPR/Cas9-mediated endogenous C-terminal tagging of Trypanosoma cruzi genes reveals the acidocalcisome localization of the inositol 1, 4, 5-trisphosphate …
Methods for genetic manipulation of Trypanosoma cruzi, the etiologic agent of Chagas
disease, have been highly inefficient, and no endogenous tagging of genes has been …
disease, have been highly inefficient, and no endogenous tagging of genes has been …
IP3 receptor-mediated Ca2+ release from acidocalcisomes regulates mitochondrial bioenergetics and prevents autophagy in Trypanosoma cruzi
In contrast to animal cells, the inositol 1, 4, 5-trisphosphate receptor of Trypanosoma cruzi
(TcIP 3 R) localizes to acidocalcisomes instead of the endoplasmic reticulum. Here, we …
(TcIP 3 R) localizes to acidocalcisomes instead of the endoplasmic reticulum. Here, we …
The journey of Ca2+ through the cell – pulsing through the network of ER membrane contact sites
Calcium is the third most abundant metal on earth, and the fundaments of its homeostasis
date back to pre-eukaryotic life forms. In higher organisms, Ca2+ serves as a cofactor for a …
date back to pre-eukaryotic life forms. In higher organisms, Ca2+ serves as a cofactor for a …
The phosphatidylinositol-transfer protein Nir3 promotes PI(4,5)P2 replenishment in response to TCR signaling during T cell development and survival
Abstract Hydrolysis of phosphatidylinositol 4, 5-bisphosphate (PIP2) by phospholipase C-γ
(PLCγ1) represents a critical step in T cell antigen receptor (TCR) signaling and subsequent …
(PLCγ1) represents a critical step in T cell antigen receptor (TCR) signaling and subsequent …