Rapid advancement in high-throughput sequencing and analytical approaches has seen a
steady increase in the generation of genomic resources for helminth parasites. Now …

How parasites develop and survive, and how they stimulate or modulate host immune
responses are important in understanding disease pathology and for the design of new …

Glutamate-gated chloride channels are the most important target of ivermectin and related
compounds in parasitic nematodes. A small family of genes encode subunits of these …

Nematode excretory-secretory (ES) products are essential for the establishment and
maintenance of infections in mammals and are valued as therapeutic and diagnostic targets …

Migrations performed by helminths are impressive and diverse, and accumulating evidence
shows that many are controlled by sophisticated sensory programs. The migrations of vector …

Recent advancements in modern science have provided robust tools for drug discovery. The
rapid development of transcriptome sequencing technologies has given rise to single-cell …

Anthelmintic resistance in equine parasite Parascaris univalens, compromises ivermectin
(IVM) effectiveness and necessitates an in-depth understanding of its resistance …

Genomics, transcriptomics, and proteomics have significantly advanced our understanding
of obligately host-associated microbes, where interrogation of the biology is often limited by …

The diversification of anthelmintic targets and mechanisms of action will help ensure the
sustainable control of nematode infections in response to the growing threat of drug …

Reconciling organism-scale biology at cellular-scale resolution has been a monumental
challenge. Recently, Gramberg et al. uncovered the spatial organisation of gene expression …