Advances in respiratory physiology in mouse models of experimental asthma

OR Carroll, AL Pillar, AC Brown, M Feng… - Frontiers in …, 2023 - frontiersin.org
Recent advances in mouse models of experimental asthma coupled with vast improvements
in systems that assess respiratory physiology have considerably increased the accuracy and …

Aging-related mechanisms contribute to corticosteroid insensitivity in elderly asthma

ML Ford, A Ruwanpathirana, BW Lewis… - International journal of …, 2023 - mdpi.com
Asthma in elderly populations is an increasing health problem that is accompanied by
diminished lung function and frequent exacerbations. As potent anti-inflammatory drugs …

Probiotic Bifidobacterium longum subsp. longum Protects against Cigarette Smoke-Induced Inflammation in Mice

KF Budden, SL Gellatly, A Vaughan, N Amorim… - International Journal of …, 2022 - mdpi.com
Bifidobacterium are prominent gut commensals that produce the short-chain fatty acid
(SCFA) acetate, and they are often used as probiotics. Connections between the gut and the …

Isthmin-1 attenuates allergic Asthma by stimulating adiponectin expression and alveolar macrophage efferocytosis in mice

JH Tee, U Vijayakumar, M Shanmugasundaram… - Respiratory …, 2023 - Springer
Background Allergic asthma is a common respiratory disease that significantly impacts
human health. Through in silico analysis of human lung RNASeq, we found that asthmatic …

Understanding Comorbidities of Respiratory Models as Novel Platforms for Drug Discovery

SN De Luca, A Gunatilaka… - ACS Pharmacology & …, 2024 - ACS Publications
Chronic respiratory diseases affect over 450 million people worldwide and result in 4 million
deaths per year. The majority of lung diseases are treated with drugs delivered directly to the …

Faecal microbial transfer and complex carbohydrates mediate protection against COPD

KF Budden, SD Shukla, KL Bowerman, A Vaughan… - Gut, 2024 - gut.bmj.com
Objective Chronic obstructive pulmonary disease (COPD) is a major cause of global illness
and death, most commonly caused by cigarette smoke. The mechanisms of pathogenesis …

Meta-Analysis and DIA-MS-Based Proteomic Investigation of COPD Patients and Asymptomatic Smokers in the Indian Population

G Sharma, DP Gupta, K Ganguly… - Journal of Proteome …, 2024 - ACS Publications
Chronic obstructive pulmonary disease (COPD) is India's second largest cause of death and
is largely caused by smoking. Asymptomatic smokers develop COPD due to genetic …

Maternal thirdhand exposure to e-cigarette vapor alters lung and bone marrow immune cell responses in offspring in the absence or presence of influenza infection

C Donovan, AE Thorpe, R Yarak… - … of Physiology-Lung …, 2024 - journals.physiology.org
There is increasing evidence that thirdhand exposure to e-cigarette vapor (e-vapor) can
have detrimental effects on the lungs. However, whether maternal exposure during …

Airway and parenchyma transcriptomics in a house dust mite model of experimental asthma

X Tu, HM Gomez, RY Kim, AC Brown, E de Jong… - Respiratory …, 2023 - Springer
Lung transcriptomics studies in asthma have provided valuable information in the whole
lung context, however, deciphering the individual contributions of the airway and …

Endotypes of Paediatric Cough—Do They Exist and Finding New Techniques to Improve Clinical Outcomes

HE O'Farrell, HC Kok, S Goel, AB Chang… - Journal of Clinical …, 2024 - mdpi.com
Chronic cough is a common symptom of many childhood lung conditions. Given the
phenotypic heterogeneity of chronic cough, better characterization through endotyping is …