Neurodegenerative diseases pose a substantial socioeconomic burden on society.
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …

Mitochondria not only supply the energy for cell function, but also take part in cell signaling.
This review describes the dysfunctions of mitochondria in aging and neurodegenerative …

The elderly population is growing worldwide, with important health and socioeconomic
implications. Clinical and experimental studies on aging have uncovered numerous …

Characterization of the key cellular targets contributing to sustained microglial activation in
neurodegenerative diseases, including Parkinson's disease (PD), and optimal modulation of …

Motor and cognitive functions depend on the coordinated interactions between dopamine
(DA) and acetylcholine (ACh) at striatal synapses. Increased ACh availability was assumed …

Quercetin, one of the major flavonoids in plants, has been recently reported to have
neuroprotective effects against neurodegenerative processes. However, since the molecular …

Cells translate extracellular signals to regulate processes such as differentiation,
metabolism and proliferation, via transmembranar receptors. G protein-coupled receptors …

Hyperpolarization-activated cyclic nucleotide–gated (HCN) channels are expressed as four
different isoforms (HCN1-4) in the heart and in the central and peripheral nervous systems …

Hyperpolarization-activated, cyclic nucleotide–gated (HCN) channels are important
members of the voltage-gated pore loop channels family. They show unique features: they …

One of the major environmental factors that induce PD is Manganese (Mn). Cellular and
molecular mechanism of parkinsonism caused by Mn has not been explored clearly. The …