Covering: 2006 to 2017 Actinomycetes have been, for decades, one of the most important
sources for the discovery of new antibiotics with an important number of drugs and analogs …

Dangerous, antibiotic resistant bacteria have been observed with increasing frequency over
the past several decades. In this review the factors that have been linked to this …

BACKGROUND: Nature has been a source of medicinal products for millennia, with many
useful drugs developed from plant sources. Following discovery of the penicillins, drug …

Historically, the majority of new drugs have been generated from natural products
(secondary metabolites) and from compounds derived from natural products. During the past …

Covering: up to mid-2020 Terpenoids, also called isoprenoids, are the largest and most
structurally diverse family of natural products. Found in all domains of life, there are over 80 …

The advent of modern antibiotics contributed enormously to the dramatic extension of
human lifespan since their discovery by virtue of their lethal and selective action against …

Despite efforts to develop new antibiotics, antibacterial resistance still develops too fast for
drug discovery to keep pace. Often, resistance against a new drug develops even before it …

Among the wide diversity of naturally occurring phenolic acids, at least 30 hydroxy-and
polyhydroxybenzoic acids have been reported in the last 10 years to have biological …

The advent of organic synthesis and the understanding of the molecule as they occurred in
the nineteenth century and were refined in the twentieth century constitute two of the most …

The pathways in Escherichia coli and (largely by analogy) S. enterica remain the paradigm
of bacterial lipid synthetic pathways, although recently considerable diversity among …