Since the initial recognition of a mechanistic role of p21-activated kinase 1 (PAK1) in breast
cancer invasion, PAK1 has emerged as one of the widely overexpressed or hyperactivated …

Microtubules (MTs) are essential for many cellular processes including establishment of cell
shape and polarity, chromosome segregation, vesicle transport, and nuclear positioning …

The post-translational modification of tubulin appears to be a highly controlled mechanism
that regulates microtubule functioning. Acetylation of the ϵ-amino group of Lys-40 of α …

Background FSGS caused by mutations in INF2 is characterized by a podocytopathy with
mistrafficked nephrin, an essential component of the slit diaphragm. Because INF2 is a …

In this study of creating new molecules from clinical trial agents, an approach of
Combretastatin structural modulation with the installation of NP-privileged motifs was …

Viruses are obligatory intracellular parasites that use cell proteins to take the control of the
cell functions in order to accomplish their life cycle. Studying the viral-host interactions would …

A wide variety of subcellular complexes are composed of one or more intrinsically
disordered proteins (IDPs) that are multivalent, flexible, and characterized by dynamic …

Rabies virus (RABV) polymerase L together with phosphoprotein P forms the PL polymerase
complex that is essential for replication and transcription. However, its exact mechanism of …

MAP7 domain containing protein 3 (MAP7D3), a newly identified microtubule associated
protein, has been shown to promote microtubule assembly and stability. Its microtubule …

Dynein light chain (DLC) proteins are an important component of dynein complexes, which
are widely distributed in plants and animals and involved in a variety of cellular processes …