Edema formation in congestive heart failure and the underlying mechanisms

Z Abassi, EE Khoury, T Karram… - Frontiers in cardiovascular …, 2022 - frontiersin.org
Congestive heart failure (HF) is a complex disease state characterized by impaired
ventricular function and insufficient peripheral blood supply. The resultant reduced blood …

Relevance of mouse models of cardiac fibrosis and hypertrophy in cardiac research

V Rai, P Sharma, S Agrawal, DK Agrawal - Molecular and cellular …, 2017 - Springer
Heart disease causing cardiac cell death due to ischemia–reperfusion injury is a major
cause of morbidity and mortality in the United States. Coronary heart disease and …

A mouse model of heart failure with preserved ejection fraction due to chronic infusion of a low subpressor dose of angiotensin II

JA Regan, AG Mauro, S Carbone… - American Journal …, 2015 - journals.physiology.org
Heart failure (HF) with preserved ejection fraction (HFpEF) is a clinical syndrome of HF
symptoms associated with impaired diastolic function. Although it represents∼ 50% of …

Renal sympathetic denervation improves pressure-natriuresis relationship in cardiorenal syndrome: insight from studies with Ren-2 transgenic hypertensive rats with …

Z Honetschlägerová, Z Husková, S Kikerlová… - Hypertension …, 2024 - nature.com
The aim was to evaluate the effects of renal denervation (RDN) on autoregulation of renal
hemodynamics and the pressure-natriuresis relationship in Ren-2 transgenic rats (TGR) with …

Impaired renal autoregulation and pressure-natriuresis: any role in the development of heart failure in normotensive and angiotensin II-dependent hypertensive rats?

Z Honetschlägerová, J Sadowski… - Hypertension …, 2023 - nature.com
The aim of the present study was to assess the autoregulatory capacity of renal blood flow
(RBF) and of the pressure-natriuresis characteristics in the early phase of heart failure (HF) …

Pulmonary, cardiac and renal distribution of ACE2, furin, TMPRSS2 and ADAM17 in rats with heart failure: Potential implication for COVID‐19 disease

EE Khoury, Y Knaney, A Fokra… - Journal of cellular …, 2021 - Wiley Online Library
Congestive heart failure (CHF) is often associated with kidney and pulmonary dysfunction.
Activation of the renin‐angiotensin‐aldosterone system (RAAS) contributes to avid sodium …

Effects of Angiotensin 1-7 and Mas Receptor Agonist on Renal System in a Rat Model of Heart Failure

R Cohen-Segev, O Nativ, S Kinaneh… - International Journal of …, 2023 - mdpi.com
Congestive heart failure (CHF) is often associated with impaired kidney function. Over-
activation of the renin–angiotensin–aldosterone system (RAAS) contributes to avid …

Current animal models for the study of congestion in heart failure: an overview

J Cops, S Haesen, B De Moor, W Mullens… - Heart failure reviews, 2019 - Springer
Congestion (ie, backward failure) is an important culprit mechanism driving disease
progression in heart failure. Nevertheless, congestion remains often underappreciated and …

Cardiac diastolic and autonomic dysfunction are aggravated by central chemoreflex activation in heart failure with preserved ejection fraction rats

C Toledo, DC Andrade, C Lucero… - The Journal of …, 2017 - Wiley Online Library
Key points Heart failure with preserved ejection fraction (HFpEF) is associated with
disordered breathing patterns, and sympatho‐vagal imbalance. Although it is well accepted …

Contribution of peripheral and central chemoreceptors to sympatho‐excitation in heart failure

C Toledo, DC Andrade, C Lucero… - The Journal of …, 2017 - Wiley Online Library
Chronic heart failure (CHF) is a major public health problem. Tonic hyper‐activation of
sympathetic neural outflow is commonly observed in patients with CHF. Importantly …