Investigations of apolipoprotein E (APOE) gene, the major genetic risk modifier for
Alzheimer's disease (AD), have yielded significant insights into the pathogenic mechanism …

Calcium signaling is critical to neuronal function and regulates highly diverse processes
such as gene transcription, energy production, protein handling, and synaptic structure and …

Although association between hearing impairment and dementia has been widely
documented by epidemiological studies, the role of auditory sensory deprivation in cognitive …

There is increasing evidence that myelin disruption is related to cognitive decline in
Alzheimer's disease (AD). In the CNS, myelin is produced by oligodendrocytes, which are …

Alzheimer's disease (AD) is the most common form of dementia. Despite enormous efforts
around the world, there remains no effective cure for AD. This study was performed to …

Impairments in neural lysosomal-and autophagic-mediated degradation of cellular debris
contribute to neuritic dystrophy and synaptic loss. While these are well-characterized …

BIN1, a member of the BAR adaptor protein family, is a significant late-onset Alzheimer
disease risk factor. Here, we investigate BIN1 function in the brain using conditional …

Neuronal hyperactivity is an early primary dysfunction in Alzheimer's disease (AD) in
humans and animal models, but effective neuronal hyperactivity-directed anti-AD …

It is well established that GluA1 mediated synaptic plasticity plays a central role in the early
development of AD. The complex cellular and molecular mechanisms that enable GluA1 …

Ca2+ homeostasis is essential for multiple neuronal functions and thus, Ca2+
dyshomeostasis can lead to widespread impairment of cellular and synaptic signaling …