Diabetic peripheral neuropathy (DPN) occurs in up to half of individuals with type 1 or type 2
diabetes. DPN results from the distal-to-proximal loss of peripheral nerve function, leading to …

Diabetes prevalence continues to climb with the aging population. Type 2 diabetes (T2D),
which constitutes most cases, is metabolically acquired. Diabetic peripheral neuropathy …

Diabetic neuropathy is one of the clinical syndromes characterized by pain and substantial
morbidity primarily due to a lesion of the somatosensory nervous system. The burden of …

Macrovascular complications such as atherosclerosis, myocardial infarction and stroke, and
microvascular complications such as nephropathy, retinopathy, and neuropathy are the …

Background Poor wound healing is a significant complication of diabetes, which is
commonly caused by neuropathy, trauma, deformities, plantar hypertension and peripheral …

Understanding the consequences of individual transcriptome variation is fundamental to
deciphering human biology and disease. We implement a statistical framework to quantify …

Vitamin B12 (B12) is an essential cofactor of two important biochemical pathways, the
degradation of methylmalonic acid and the synthesis of methionine from homocysteine …

Significance: Reactive oxygen species (ROS) contribute to multiple aspects of peripheral
nervous system (PNS) biology ranging from physiological processes (eg, axonal outgrowth …

Background Diabetic peripheral neuropathy (DPN) is the most common complication of type
2 diabetes (T2D). Although the cellular and molecular mechanisms of DPN are poorly …

Diabetic neuropathy (DN), the most common chronic and progressive complication of
diabetes mellitus (DM), strongly affects patients' quality of life. DN could be present as …