Nanomaterials targeting tumor associated macrophages for cancer immunotherapy
Tumor-associated macrophages (TAMs) play an important role in regulating tumor growth,
invasion and metastasis, and constitute approximately 50% of tumor mass. TAMs can exist …
invasion and metastasis, and constitute approximately 50% of tumor mass. TAMs can exist …
The CD47-SIRPα axis is a promising target for cancer immunotherapies
Y Hao, X Zhou, Y Li, B Li, L Cheng - International Immunopharmacology, 2023 - Elsevier
Abstract Cluster of differentiation 47 (CD47) is a transmembrane protein that is ubiquitously
found on the surface of many cells in the body and uniquely overexpressed by both solid …
found on the surface of many cells in the body and uniquely overexpressed by both solid …
A siRNA-assisted assembly strategy to simultaneously suppress “self” and upregulate “eat-me” signals for nanoenabled chemo-immunotherapy
Effectively activating macrophages that can engulf cancer cells is a promising
immunotherapeutic strategy but remains a major challenge due to the expression of “self” …
immunotherapeutic strategy but remains a major challenge due to the expression of “self” …
Nanoparticle-based immunoengineering strategies for enhancing cancer immunotherapy
Cancer immunotherapy is a groundbreaking strategy that has revolutionized the field of
oncology compared to other therapeutic strategies, such as surgery, chemotherapy, or …
oncology compared to other therapeutic strategies, such as surgery, chemotherapy, or …
Recent advances of tumor therapy based on the CD47-SIRPα axis
Y Wang, C Zhao, Y Liu, C Wang, H Jiang… - Molecular …, 2022 - ACS Publications
Cancer is still a major disease that is currently difficult for humans to overcome. When the
expression of the cluster of differentiation 47 (CD47) is upregulated, tumor cells interact with …
expression of the cluster of differentiation 47 (CD47) is upregulated, tumor cells interact with …
Plasma membrane abundance dictates phagocytic capacity and functional cross-talk in myeloid cells
BY Winer, AH Settle, AM Yakimov, C Jeronimo… - Science …, 2024 - science.org
Professional phagocytes like neutrophils and macrophages tightly control what they
consume, how much they consume, and when they move after cargo uptake. We show that …
consume, how much they consume, and when they move after cargo uptake. We show that …
Suppressing or enhancing macrophage engulfment through the use of CD47 and related peptides
AAR Jalil, MP Tobin, DE Discher - Bioconjugate chemistry, 2022 - ACS Publications
Foreign particles and microbes are rapidly cleared by macrophages in vivo, although many
key aspects of uptake mechanisms remain unclear.“Self” cells express CD47 which …
key aspects of uptake mechanisms remain unclear.“Self” cells express CD47 which …
[HTML][HTML] CD47-SIRPα axis in cancer therapy: precise delivery of CD47-targeted therapeutics and design of anti-phagocytic drug delivery systems
J Zhu, C Cai, J Li, J Xiao, X Duan - Medicine in Drug Discovery, 2022 - Elsevier
As a “marker of self”, CD47 is expressed on the surface of all cells in humans, mice, and
other mammals to inhibit phagocytic destruction of normal cells through interacting with …
other mammals to inhibit phagocytic destruction of normal cells through interacting with …
The potential mechanism of concentrated mannan-oligosaccharide promoting goldfish's (Carassius auratus Linnaeus) resistance to Ichthyophthirius multifiliis invasion
S Liu, M Xu, B Chen, F Li, Y Deng, Y Zhang… - Fish & Shellfish …, 2024 - Elsevier
Because of the low host specificity, Ichthyophthirius multifiliis (Ich) can widely cause white
spot disease in aquatic animals, which is extremely difficult to treat. Prior research has …
spot disease in aquatic animals, which is extremely difficult to treat. Prior research has …
Immunomodulatory Peptides for Tumor Treatment
Y Song, L Lei, X Cai, H Wei… - Advanced Healthcare …, 2024 - Wiley Online Library
Peptides exhibit various biological activities, including biorecognition, cell targeting, and
tumor penetration, and can stimulate immune cells to elicit immune responses for tumor …
tumor penetration, and can stimulate immune cells to elicit immune responses for tumor …