Tumor-associated macrophages (TAMs) play an important role in regulating tumor growth,
invasion and metastasis, and constitute approximately 50% of tumor mass. TAMs can exist …

Abstract Cluster of differentiation 47 (CD47) is a transmembrane protein that is ubiquitously
found on the surface of many cells in the body and uniquely overexpressed by both solid …

Effectively activating macrophages that can engulf cancer cells is a promising
immunotherapeutic strategy but remains a major challenge due to the expression of “self” …

Cancer immunotherapy is a groundbreaking strategy that has revolutionized the field of
oncology compared to other therapeutic strategies, such as surgery, chemotherapy, or …

Cancer is still a major disease that is currently difficult for humans to overcome. When the
expression of the cluster of differentiation 47 (CD47) is upregulated, tumor cells interact with …

Professional phagocytes like neutrophils and macrophages tightly control what they
consume, how much they consume, and when they move after cargo uptake. We show that …

Foreign particles and microbes are rapidly cleared by macrophages in vivo, although many
key aspects of uptake mechanisms remain unclear.“Self” cells express CD47 which …

As a “marker of self”, CD47 is expressed on the surface of all cells in humans, mice, and
other mammals to inhibit phagocytic destruction of normal cells through interacting with …

Because of the low host specificity, Ichthyophthirius multifiliis (Ich) can widely cause white
spot disease in aquatic animals, which is extremely difficult to treat. Prior research has …

Peptides exhibit various biological activities, including biorecognition, cell targeting, and
tumor penetration, and can stimulate immune cells to elicit immune responses for tumor …