DNA methylation aging clocks: challenges and recommendations
Epigenetic clocks comprise a set of CpG sites whose DNA methylation levels measure
subject age. These clocks are acknowledged as a highly accurate molecular correlate of …
subject age. These clocks are acknowledged as a highly accurate molecular correlate of …
Epigenetic therapies for cancer
SE Bates - New England Journal of Medicine, 2020 - Mass Medical Soc
Epigenetic Therapies for Cancer | New England Journal of Medicine Skip to main content The
New England Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES …
New England Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES …
Inferring gene expression from cell-free DNA fragmentation profiles
Profiling of circulating tumor DNA (ctDNA) in the bloodstream shows promise for
noninvasive cancer detection. Chromatin fragmentation features have previously been …
noninvasive cancer detection. Chromatin fragmentation features have previously been …
[HTML][HTML] The emerging role of cell-free DNA as a molecular marker for cancer management
AJ Bronkhorst, V Ungerer, S Holdenrieder - Biomolecular detection and …, 2019 - Elsevier
An increasing number of studies demonstrate the potential use of cell-free DNA (cfDNA) as a
surrogate marker for multiple indications in cancer, including diagnosis, prognosis, and …
surrogate marker for multiple indications in cancer, including diagnosis, prognosis, and …
Practical implementation of DNA methylation and copy-number-based CNS tumor diagnostics: the Heidelberg experience
Recently, we described a machine learning approach for classification of central nervous
system tumors based on the analysis of genome-wide DNA methylation patterns [6]. Here …
system tumors based on the analysis of genome-wide DNA methylation patterns [6]. Here …
Plasma DNA tissue mapping by genome-wide methylation sequencing for noninvasive prenatal, cancer, and transplantation assessments
Plasma consists of DNA released from multiple tissues within the body. Using genome-wide
bisulfite sequencing of plasma DNA and deconvolution of the sequencing data with …
bisulfite sequencing of plasma DNA and deconvolution of the sequencing data with …
DNA methylation: an epigenetic mark of cellular memory
M Kim, J Costello - Experimental & molecular medicine, 2017 - nature.com
DNA methylation is a stable epigenetic mark that can be inherited through multiple cell
divisions. During development and cell differentiation, DNA methylation is dynamic, but …
divisions. During development and cell differentiation, DNA methylation is dynamic, but …
DNA methylation-based classification of central nervous system tumours
Accurate pathological diagnosis is crucial for optimal management of patients with cancer.
For the approximately 100 known tumour types of the central nervous system …
For the approximately 100 known tumour types of the central nervous system …
Epigenetic profiling to classify cancer of unknown primary: a multicentre, retrospective analysis
Background Cancer of unknown primary ranks in the top ten cancer presentations and has
an extremely poor prognosis. Identification of the primary tumour and development of a …
an extremely poor prognosis. Identification of the primary tumour and development of a …
methylKit: a comprehensive R package for the analysis of genome-wide DNA methylation profiles
DNA methylation is a chemical modification of cytosine bases that is pivotal for gene
regulation, cellular specification and cancer development. Here, we describe an R package …
regulation, cellular specification and cancer development. Here, we describe an R package …